The oral Bioavailability of BCS (Bio Pharmaceutical Classification System) class II drug with poor solubility and reasonable permeability is limited by drug dissolution. The purpose of this research was to obtain enhancement of the dissolution profile and Flow Properties of Loratadine using solid dispersion technique with hydrophilic polymers such as Beta-cyclodextrin. Solid dispersions were prepared by the method of solvent evaporation. Prepared dispersion was evaluated for physical appearance, flow property (Angel of repose, Bulk and Tapped density, Compressibility index, Hausner ratio), Drug content, Dissolution studies using the USP paddle method were performed for solid dispersions of Loratadine & pure drug. The resulting systems were subjected to Infrared (IR) spectroscopy to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. IR spectroscopy, showed no change in the chemical structure of Loratadine. The solid dispersion technique can be successfully used for improvement of dissolution of Loratadine. The Dissolution rates & Dissolution efficiency of Loratadine from the Solid Dispersions exhibited higher values over that of pure drugs.
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